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. 2023 Oct 20;14:6538. doi: 10.1038/s41467-023-42260-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Structural alignment of the agonist-binding pocket of H₄R_his (pink) and H₄R_ime (blue). Histamine (yellow), imetit (magenta), and the surrounding residues of each agonist are shown as sticks. b, c Hydrophobic residue cluster of TM7 and 8 in H₄R_his (b) and H₄R_ime (c). The side chain rearrangement of Phe344^7.39 forms the aromatic slot on H₄R_ime. Residues comprising the pocket are indicated by sticks and transparent spheres and are pink (H₄R_his) and blue (H₄R_ime).