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. Author manuscript; available in PMC: 2023 Oct 21.
Published in final edited form as: Nat Rev Dis Primers. 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7

Figure 3. Pathogenetic mechanism of sporadic YO-CRC.

Figure 3.

Examples of risk factors, during the life-course that may be involved in the development of young-onset colorectal cancer (YO-CRC), including environmental exposures, medication use and diet. All these factors influence the gut microbiota, creating a susceptible environment for CRC by inducing inflammation, suppressing immunity and promoting tumour growth.