Table 2.
Age-standardized outcomes per 1000 person-years according to geographic region and sex.
| Cardiovascular disease events | All-cause deaths | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Women | Men | Women | Men | |||||||||
| Region | No. of events | 10-year % (95% CI) | Per 1000 person-years (95% CI) | No. of events | 10-year % (95% CI) | Per 1000 person-years (95% CI) | No. of events | 10-year % (95% CI) | Per 1000 person-years (95% CI) | No. of events | 10-year % (95% CI) | Per 1000 person-years (95% CI) |
| Global | 30,033 | 4.0 (4.0, 4.1) | 5.2 (5.2, 5.3) | 50,563 | 7.8 (7.7, 7.9) | 9.9 (9.8, 10.0) | 78,608 | 6.1 (6.0, 6.2) | 9.0 (9.0, 9.1) | 98,761 | 9.3 (9.2, 9.4) | 13.4 (13.3, 13.4) |
| North America | 4702 | 7.4 (7.1, 7.8) | 10.1 (9.8, 10.4) | 5321 | 13.7 (13.1, 14.2) | 16.6 (16.2, 17.1) | 8674 | 7.6 (7.3, 8.0) | 16.7 (16.4, 17.0) | 8128 | 11.3 (10.8, 11.8) | 21.4 (20.9, 21.8) |
| Latin America * | 71 | - | 2.4 (1.9, 3.1) | 89 | - | 4.1 (3.3, 5.0) | 12,488 | 6.8 (6.6, 7.0) | 7.5 (7.4, 7.7) | 9733 | 9.7 (9.5, 10.0) | 10.7 (10.4, 10.9) |
| Western Europe | 22,212 | 3.7 (3.6, 3.8) | 4.9 (4.8, 4.9) | 40,942 | 7.3 (7.2, 7.5) | 9.6 (9.5, 9.7) | 42,676 | 5.6 (5.5, 5.7) | 8.9 (8.8, 9.0) | 59,447 | 8.4 (8.3, 8.5) | 12.7 (12.6, 12.8) |
| Eastern Europe and Russia | 1078 | 5.7 (5.0, 6.4) | 8.7 (7.9, 9.5) | 1508 | 9.9 (8.9, 10.9) | 13.5 (12.4, 14.6) | 3255 | 10.1 (9.5, 10.7) | 12.7 (12.2, 13.3) | 4827 | 17.9 (17.1, 18.6) | 22.1 (21.4, 22.8) |
| North Africa and Middle East | 1146 | 6.4 (5.6, 7.2) | 4.0 (3.7, 4.3) | 1805 | 9.4 (8.5, 10.2) | 6.8 (6.5, 7.2) | 1650 | 8.1 (7.2, 9.0) | 6.1 (5.7, 6.5) | 8615 | 11.9 (11.3, 12.5) | 16.2 (15.8, 16.6) |
| Sub-Saharan Africa ** | 3 | - | 0.1 (0.0, 0.2) | 1 | - | 0.0 (0.0, 0.2) | 431 | 27.2 (16.0, 36.9) | 14.1 (12.7, 15.6) | 456 | 34.6 (25.1, 42.9) | 26.7 (24.1, 29.6) |
| Asia | 311 | 2.5 (1.8, 3.2) | 2.5 (2.2, 2.9) | 353 | 4.2 (3.0, 5.4) | 5.1 (4.5, 5.9) | 6399 | 11.0 (9.9, 12.0) | 7.6 (7.1, 8.1) | 4751 | 16.7 (15.1, 18.4) | 12.0 (11.2, 13.0) |
| Australia | 510 | 4.9 (4.3, 5.5) | 6.0 (5.4, 6.6) | 544 | 9.2 (8.3, 10.1) | 10.3 (9.4, 11.4) | 3035 | 4.7 (4.5, 5.0) | 5.6 (5.4, 5.9) | 2804 | 7.2 (6.8, 7.6) | 8.9 (8.5, 9.3) |
Computations were performed using 1,088,670 individuals for cardiovascular disease and 1,419,699 individuals for all-cause mortality. Ten-year percentage of events were estimated using the Kaplan-Meier estimator. Events per person year were estimated using the complete follow-up and a Poisson regression with log-transformed follow-up time as an offset. Direct standardization according to the age distribution of the Global Cardiovascular Risk Consortium dataset was used when computing ten-year percentage of events and events per person years per geographic region. For the standardization the following age groups were considered: age ≤40 years; 40< to ≤45; 45< to ≤50; 55< to ≤60; 65< to ≤70; and >70 years. Confidence interval widths have not been adjusted for multiplicity and should not be used in place of hypothesis testing.
Since the CVD follow-up in Latin America is shorter than 10 years, it is not possible to obtain an estimate of the 10-year probability of event using the Kaplan-Meier estimator.
Due to low number of CVD events recorded, the 10-year percentage of events and events per person year were not estimated. CI: Confidence Interval.