Table 3.
Receiver Operating Curve Analysis of Endocannabinoids and Inflammatory Biomarkers in Prediction of Invasive Mechanical Ventilation Requirement and Length of Hospital Stay Greater Than 10 Days in Sepsis
| Variable | AUC (95% CI) | p | Cutoff | Sensitivity, % (95% CI) | Specificity, % (95% CI) | LR+ (95% CI) | LR− (95% CI) |
|---|---|---|---|---|---|---|---|
| Invasive mechanical ventilation | |||||||
| AEA (μg/L) | 0.63 (0.53–0.72) | 0.032 | ≤21.64 | 100 (87–100) | 28 (18–39) | 1.4 (1.2–1.6) | 0 |
| 2-AG (μg/L) | 0.70 (0.60–0.79) | <0.001 | ≤6.60 | 69 (48–86) | 69 (57–79) | 2.2 (1.5–3.4) | 0.5 (0.2–0.8) |
| CRP (mg/L) | 0.67 (0.58–0.76) | 0.005 | >227.6 | 77 (56–91) | 60 (48–71) | 1.9 (1.4–2.7) | 0.4 (0.2–0.8) |
| PCT (μg/L) | 0.62 (0.52–0.71) | 0.057 | >4.21 | 69 (48–86) | 58 (46–69) | 1.6 (1.1–2.3) | 0.5 (0.3–1.0) |
| IL-6 (ng/L) | 0.62 (0.52–0.71) | 0.053 | >69.1 | 77 (56–91) | 54 (42–65) | 1.7 (1.2–2.3) | 0.4 (0.2–0.9) |
| WBC (×109/L) | 0.53 (0.44–0.63) | 0.610 | ≤14.9 | 69 (48–86) | 45 (34–57) | 1.3 (0.9–1.7) | 0.7 (0.4–1.3) |
| Length of stay for 10 or more days (LOS ≥10) | |||||||
| AEA (μg/L) | 0.63 (0.53–0.72) | 0.021 | ≤17.84 | 98 (89–100) | 34 (22–47) | 1.48 | 0.06 |
| 2-AG (μg/L) | 0.55 (0.45–0.65) | 0.350 | ≤15.40 | 79 (64–89) | 39 (27–53) | 1.29 | 0.55 |
| CRP (mg/L) | 0.59 (0.49–0.69) | 0.094 | >187.1 | 85 (72–94) | 39 (27–53) | 1.39 | 0.38 |
| PCT (μg/L) | 0.54 (0.40–0.67) | 0.641 | ≥48.6 | 97 (82–100) | 24 (10–44) | 1.27 | 0.14 |
| IL-6 (ng/L) | 0.51 (0.41–0.61) | 0.872 | >154.9 | 17 (8–31) | 63 (49–75) | 0.46 | 1.32 |
| WBC (×109/L) | 0.57 (0.47–0.67) | 0.188 | >11.3 | 72 (57–84) | 44 (31–58) | 1.29 | 0.63 |
AUC, area under the curve; LR, likelihood ratio; PCT, procalcitonin; WBC, white blood cells.