Skip to main content
. 2023 Oct 9;8(5):824–834. doi: 10.1089/can.2021.0098

FIG. 1.

FIG. 1.

Inhalant CBD inhibits tumor growth and improved survival in GBM. (a) Optical imaging (bioluminescence imaging after injecting luciferin) showed the establishment and growth of GBM tumor on day 8 post-implantation. (b) Tumor growth was inhibited after eight consecutive daily treatments of inhalant CBD compared to the placebo-treated group as optical bioluminescence images were quantified (*p>0.05) (c). (d) Mice were treated with CBD/placebo using inhaler ApelinDx. (e) H&E staining suggested significant decrease in tumor size after CBD treatment compared to placebo. The difference in tumor size between CBD- and placebo-treated groups (p<0.05) was quantified using ImageJ Java-based image processing program (*p>0.05) (f). (g) Survival was evaluated (n=6/group), showed that, while all animals in CBD-treated group were alive at 16 days after orthotopic implantation of the tumor, however, 50% of animals from placebo group (3/6) died by day 13 post-implantation, suggesting beneficial effects of CBD treatment. GBM, glioblastoma; H&E, hematoxylin and eosin. Color images are available online.