Immunohistochemical staining of paraffin-embedded GBM tumor tissues showed inhalant CBD decreased expression of angiogenic factors: (a) P-selectin, (b) apelin, and (c) IL-8 significantly compared to the placebo treated group as quantified (*p>0.05; **p>0.01) (d). All images have been obtained using bright field Zeiss (AXIO Imager M2) light microscope, magnifications of 200×and 630×. IL, interleukin; TME, tumor microenvironment. Color images are available online.