Table 2.
Distance Between Select Residues in CB1 Crystal and Cryo-EM Structures
| Residue-atom | PDB-ID | Bound ligand | Distance (Å) |
|---|---|---|---|
| D2.50-OD1 and N7.49-ND2 | |||
| 5U09 | Taranabant | 3.62 | |
| 5XRA | AM11542 | 4.52 | |
| 6KQI | ORG/CP55,940 | 4.50 | |
| 6KPG | AM841/Gi | 5.04 | |
| D2.50-OD2 and N7.49-ND2 | |||
| 5U09 | Taranabant | 3.61 | |
| 5XRA | AM11542 | 3.62 | |
| 6KQI | ORG/CP55,940 | 2.77a | |
| 6KPG | AM841/Gi | 3.91 | |
| D2.50-OD2 and Y7.53-OH | |||
| 5U09 | Taranabant | 3.63 | |
| 5XRA | AM11542 | 9.16 | |
| 6KQI | ORG/CP55,940 | 5.06b | |
| 6KPG | AM841/Gi | 9.45 | |
Data from the Worldwide PDB database (X-ray crystallography and cryo-EM structures). Taranabant: inverse agonist. AM11542, AM841, and CP55,940: orthosteric agonists. ORG: ORG27569, allosteric β-arrestin-biased ligand.
a
Indicates a distance permissive to direct hydrogen bonding.
b
Indicates a distance permissive to hydrogen bonding via a water molecule.
EM, electron microscopy; PDB, Protein Data Bank.