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. 2023 Oct 10;120(42):e2307972120. doi: 10.1073/pnas.2307972120

Fig. 2.

Fig. 2.

ND1 programs neuronal conversion from microglia/macrophages in the ischemic striatum. (A) Quantification of the indicated marker-positive cells in the striatum at 2 wpi (n = 4 per group). *P < 0.05, two-tailed Mann–Whitney U test. (B and C) Representative images of staining for EGFP (green)-, βIII-tubulin (red)-, and Map2ab (cyan)-positive cells in the ischemic area of control (B) and ND1 (C) virus-treated mice at 2 wpi (Scale bars, 50 μm). (D) Quantification of the indicated marker-positive cells in (B) and (C) (n = 4 per group). *P < 0.05, two-tailed Mann–Whitney U test. (E) Schematic representation of microglial depletion from the brain. (F) Representative images of staining for Tmem119 (red) in the striatum contralateral to the lesion in tMCAO mice treated with control or PLX diets at 2 wpi (Scale bar, 50 μm). (G) Representative images of staining for EGFP (green) and Map2ab (red) in the ischemic area of the striatum in tMCAO mice treated with control or PLX diets at 2 wpi (Scale bar, 50 μm). (H) Quantification of the indicated marker-positive cells in (G) (n = 4 per group). *P < 0.05, two-tailed Mann–Whitney U test.