TABLE 1.
Comparison of the activities of LY333328 and five other antibiotics on MH II agar against 195 VRE strains
| Antibiotic | MIC (μg/ml)
|
||
|---|---|---|---|
| 50% | 90% | Range | |
| LY333328a | 4 | 8 | 0.25–8 |
| Teicoplanin | 64 | 128 | ≤0.125–>128 |
| Vancomycin | 512 | 1,024 | 32–>1,024 |
| Quinupristin-dalfopristin | 2 | 4 | 0.5–32 |
| Ampicillin | 256 | 512 | 1–>512 |
| Gentamicin | >2,048 | >2,048 | 4–>2,048 |
The same strains tested in MH II broth by microdilution had an MIC50 of 2 μg/ml and an MIC90 of 4 μg/ml (range, ≤0.125 to 4 μg/ml).