TABLE 4.

Bacterial killing of two VRE strains by LY333328, ampicillin, and LY333328 plus ampicillin

Antibiotic(s)	Concentration (no. of times the MIC)	Bacterial killing (log10 CFU/ml)a
		Strain VRE-30b				Strain VRE-31c
		2 h	6 h	24 h	48 h	2 h	6 h	24 h	48 h
LY333328	0	+1.27	+2.36	+3.72	+3.65	+1.20	+3.10	+3.80	+3.90
	4	−0.97	−2.30	−2.99	+2.27	−0.26	−0.24	+0.82	+3.26
	10	−2.15	>−4.0	>−4.0	>−4.0	+0.13	+0.06	+3.17	+3.63
	20	−1.30	>−4.0	>−4.0	>−4.0	−0.17	−0.20	+0.87	+2.70
	30	−2.17	>−4.0	>−4.0	>−4.0	ND	ND	ND	ND
	40	NDd	ND	ND	ND	−0.43	−0.74	−3.59	−3.70
Ampicillin	4	−0.78	−1.62	−4.24	−3.62	−0.58	−0.94	−2.64	−2.74
	10	−0.57	−0.89	>−4.0	−3.87	−0.55	−0.83	−2.77	−2.48
	20	−0.82	−1.45	−4.14	>−4.0	−0.44	−0.85	−1.93	−2.83
	30	−0.76	−1.10	>−4.0	−3.88	ND	ND	ND	ND
	40	ND	ND	ND	ND	−0.43	−0.74	−3.23	−4.82
LY333328 + ampicillin	4	−2.50	>−4.0	>−4.0	−3.67	−0.27	−0.20	−0.63	−2.52
	10	−3.0	>−4.0	>−4.0	>−4.0	−0.26	−0.67	−1.89	−2.67
	20	>−3.0	>−4.0	>−3.0	>−3.0	−0.40	−0.70	−1.83	−3.61
	30	>−3.0	>−4.0	>−3.0	>−3.0	ND	ND	ND	ND
	40	ND	ND	ND	ND	−0.47	−0.86	−3.13	>−5.0

^aBacterial count following incubation minus initial inoculum (10⁵ CFU/ml). A negative value indicates net killing, and a positive value indicates net growth. 

^bMIC = 0.125 μg of LY 333328 per ml and 16 μg of ampicillin per ml. 

^cMIC = 0.06 μg of LY333328 per ml and 4 μg of ampicillin per ml. 

^dND, not done.