Comparison 1. Antifibrinolytics versus control (all trauma).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	3	20437	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.85, 0.96]
1.1 Tranexamic acid	2	20367	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.85, 0.97]
1.2 Aprotinin	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	0.14 [0.01, 2.67]
2 Myocardial infarction	2	20367	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.40, 0.92]
3 Stroke	2	20367	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.61, 1.23]
4 Deep vein thrombosis	2	20367	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.62, 1.47]
5 Pulmonary embolism	2	20367	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.73, 1.41]
6 Surgical intervention	3	20437	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.97, 1.03]
6.1 Tranexamic acid	2	20367	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.97, 1.03]
6.2 Aprotinin	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.87, 1.33]
7 Blood transfusion	2	20367	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.96, 1.01]
8 Volume of blood transfused	2	20197	Mean Difference (IV, Fixed, 95% CI)	‐0.21 [‐0.41, ‐0.01]
8.1 Tranexamic acid	1	20127	Mean Difference (IV, Fixed, 95% CI)	‐0.17 [‐0.39, 0.05]
8.2 Aprotinin	1	70	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.91, 0.11]