1. Summary of results and GRADE assessments.
| Antidepressants compared with treatment as usual for postnatal depression | |||||
| Outcomes |
Raw data by group % (no of women) |
Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments |
| Remission | Antidepressants: 37% (48/129) Treatment as usual: 18% (22/125) |
Sharp 2010: RR 2.11 (1.36 to 3.28) |
254 (1 study) | ⊕⊝⊝⊝ very low1,2 | Sharp 2010: remission: < 13 EPDS (4 weeks) |
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1 downgraded twice due to high risk of bias in two domains (lack of blinding of outcome assessors and low adherence)
2 downgraded due to imprecision (only one study available for this comparison)
EPDS: Edinburgh Postnatal Depression Scale; RR: risk ratio.