3. Summary of results and GRADE assessments.
| Antidepressant (sertraline) compared with other antidepressant (nortriptyline) for postnatal depression | |||||
| Outcomes |
Raw data by group % (no of women) |
Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments |
| Response | Sertraline: 56% (31/55) Nortriptyline: 69% (37/54) |
Wisner 2006: RR 0.82 (0.61 to 1.10) |
109 (1 study) | ⊕⊕⊝⊝ low1,2 |
Wisner 2006: response: 50% reduction in HAM‐D from baseline (at 8 weeks) |
| Remission | Sertraline: 46% (25/55) Nortriptyline: 48% (26/54) |
Wisner 2006: RR 0.94 (0.63 to 1.41) |
109 (1 study) | ⊕⊕⊝⊝ low1,2 |
Wisner 2006: remission: HAM‐D < 7 (at 8 weeks) |
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1 downgraded due to risk of bias (incomplete outcome data owing to loss to follow‐up)
2 downgraded due to imprecision (only 1 study available for this comparison)
HAM‐D: Hamilton Rating Scale for Depression; RR: risk ratio.