Table 1.
Baseline characteristics of healthy controls and the infertile patients recruited to study the prevalence of subclinical hypothyroidism, and of the previously infertile patients recruited for follow-up during pregnancy.
| No. | Age (y.) | Age at menarche (y.) | Duration of menstrual cycle (d.) | BMI (kg/m2) | RR systolic (mm Hg) | RR diastolic (mm Hg) | Heartbeat frequency (per min) | Baseline TSH (mIU/l) | Baseline anti-TPO (IU/l) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Prevalence study | ||||||||||
| Infertile patients | 155 | 33.7 ± 0.7 | 13.3 ± 0.3 | 28.1 ± 0.9 | 23.0 ± 0.6 | 122.1 ± 2.1 | 72.0 ± 0.4 | 72.0 ± 1.6 | 1.94 ± 1.50 | 22.7 ± 8.5 |
| Healthy controls | 154 | 32.3 ± 0.9 | 13.0 ± 0.2 | 27.5 ± 0.4 | 23.2 ± 0.6 | 124.9 ± 1.9 | 73.4 ± 1.2 | 72.5 ± 1.6 | 1.73 ± 1.20 | 47.7 ± 18.0 |
| ANOVA | F(1, 306) = 5.7 P = 0.018 | F(1, 306) = 2.8 P = 0.094 | F(1, 306) = 1.3 P = 0.252 | F(1, 306) = 0.1 P = 0.722 | F(1, 306) = 3.6 P = 0.058 | F(1, 306) = 1.8 P = 0.182 | F(1, 306) = 1.8 P = 0.182 | F(1, 306) = 0 P = 0.840 | F(1, 306) = 3.9 P = 0.049 | |
| Pregnancy follow-up study | ||||||||||
| Group 1 | 17 | 33.4 ± 2.1 | 13.4 ± 0.7 | 30.6 ± 1.9 | 24.9 ± 2.2 | 123.3 ± 5.2 | 74.2 ± 3.7 | 73.5 ± 4.9 | 1.5 ± 0.2 | 10.1 ± 0.2 |
| Group 2 | 14 | 32.9 ± 1.5 | 12.9 ± 0.9 | 33.9 ± 8.6 | 23.8 ± 1.9 | 124.6 ± 7.2 | 75.6 ± 5.2 | 75.2 ± 8.2 | 3.4 ± 0.3 | 11.3 ± 2.5 |
| Group 3 | 17 | 32.8 ± 2.0 | 12.9 ± 0.9 | 28.5 ± 1.2 | 23.7 ± 2.5 | 117.8 ± 5.3 | 70.8 ± 3.6 | 72.7 ± 4.7 | 5.9 ± 0.6 | 13.3 ± 3.6 |
| Group 4 | 9 | 31.0 ± 2.9 | 13.4 ± 1.2 | 35.2 ± 13.4 | 25.2 ± 4.7 | 123.7 ± 10.6 | 72.4 ± 5.7 | 74.9 ± 6.9 | 2.1 ± 0.4 | 264 ± 199 |
| Group 5 | 12 | 33.0 ± 2.8 | 13.1 ± 1.0 | 30.0 ± 2.8 | 23.6 ± 1.9 | 124.3 ± 7.3 | 74.3 ± 5.5 | 72.9 ± 3.1 | 3.8 ± 0.6 | 429 ± 172 |
| Group 6 | 16 | 33.9 ± 2.0 | 13.5 ± 0.8 | 29.4 ± 2.4 | 21.8 ± 1.6 | 118.9 ± 7.3 | 74.3 ± 5.1 | 73.9 ± 4.6 | 8.0 ± 2.1 | 1035 ± 506 |
| ANOVA | F(5, 79) = 0.6 P = 0.710 | F(5, 79) = 0.4 P = 0.862 | F(5, 79) = 0.9 P = 0.501 | F(5, 79) = 0.2 P = 0.990 | F(5, 79) = 0.8 P = 0.562 | F(5, 79) = 0.5 P = 0.742 | F(5, 79) = 0.1 P = 0.987 | F(5, 79) = 22.5 P < 0.00001 | F(5, 79) = 11.4 P < 0.00001 | |
Group 1: TSH <2.5 mIU/l and anti-TPO <100 IU/ml.
Group 2: TSH >2.5–4.5 mIU/l and anti-TPO <100 IU/ml.
Group 3: TSH > 4.5 mIU/l and anti-TPO <100 IU/ml.
Group 4: TSH <2.5 mIU/l and anti-TPO >100 IU/ml.
Group 5: TSH >2.5–4.5 mIU/l and anti-TPO >100 IU/ml.
Group 6: TSH > 4.5 mIU/l and anti-TPO >100 IU/ml.
TSH, thyroid-stimulating hormone; anti-TPO, thyroid peroxidase antibodies; RR: risk ratio.