Table 3.

Summary of grading systems of CRS

NIH CTCAE (Version 5.0)
Grade	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
CTCAE (Symptoms and Signs)	Fever with or without constitutional symptoms	Hypotension responding to fluids; hypoxia responding to < 40% O2	Hypotension managed with one pressor; hypoxia requiring ≥ 40% O2	Life-threatening consequences; urgent intervention indicated	Death

Lee’s modified grading system
Lee’s criteria (Symptoms and Signs)	(i) Symptoms are not life-threatening and require symptomatic treatment only,	(i) Symptoms require and respond to moderate intervention (ii) Oxygen requirement < 40% (iii) Hypotension responsive to fluids or low dose of one vasopressor (iv) Grade 2 organ toxicity	(i) Symptoms require and respond to aggressive intervention (ii) Oxygen requirement ≥ 40% (iii) Hypotension requiring high dose or multiple vasopressors (iv) Grade 3 organ toxicity or grade 4 transaminitis	(i) Life-threatening symptoms (ii) Requirement for ventilator support (iii) Grade 4 organ toxicity (excluding transaminitis)	Death
Treatment recommendation	Supportive care	Supportive care or supportive care + Tocilizumab ± corticosteroids	Supportive care + Tocilizumab ± corticosteroids	Supportive care + Tocilizumab ± corticosteroids	N/A

ASTCT grading system
Fever	Temperature ≥ 38 °C	Temperature ≥ 38 °C	Temperature ≥ 38 °C	Temperature ≥ 38 °C	Death
With
Hypotension	None	Not requiring vasopressors	Requiring a vasopressor with or without vasopressin	Requiring multiple vasopressors (excluding vasopressin)	Death
And/Or
Hypoxia	None	Requiring low-flow nasal cannula or blow-by	Requiring high-flow nasal cannula, facemask, nonrebreather mask, or Venturi mask	Requiring positive pressure (e.g., CPAP, BiPAP, intubation, and mechanical ventilation)	Death