Table 3.

Injection Techniques for Popular Off-Label Indications

Indication	Dose Range	Depth	Technique
Nasal rhytids (bunny lines)	3–4 U	Superficial	Inject high up on the nose, to the sides of the bridge of the nose and into the area of maximum wrinkling. Inject superficially into skin overlying nasalis muscle.
Cobblestone chin	3–4 U	Deep	Inject two points adjacent to midline close to origin of mentalis muscle.
Changing eye silhouette to almond shape	1 U	Superficial	Inject into the center of the lower lash-line into the pretarsal section of the orbicularis oculi muscle. This creates widening of the eye. As the muscle relaxes, the eye becomes more oval or almond shaped.
Changing brow shape	2–3 U per injection point	Superficial	Inject 3 points on the orbicularis oculi: (1) First injection site medial two thirds of brow meeting lateral third of brow (3 U); (2) second injection site 2–3 cm lateral and 1 cm inferior to first injection point, just under hairy part of eyebrow (2U); (3) third injection point on line joining lateral canthus with orbital bone, 1 cm lateral to the bone (3–4U). Also inject two to three points on uppermost fibers of the frontalis muscle close to the hairline (1U each injection site) to induce the compensation force of the lower lateral frontalis muscle fibers.
Raise corners of mouth	3–4 U/side	Muscular	Inject origin of depressor anguli oris muscle at the level of the mandible.
Platysmal bands	3–5 U per injection point	Deep	Inject 3–5 U into each injection site tracing the bands from mandible to the clavicle.
Improving skin quality	0.25 U or less per injection point	Intradermal	Hyperdilute by mixing 10 U neurotoxin with 1–2 mL normal saline or lidocaine. Inject intradermally avoiding areas of origin or insertion of muscles of facial movement.