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. 2023 Oct 21;9:387. doi: 10.1038/s41420-023-01688-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A1/2, B1/2 VAX2 and/or hnRNPF expression detected using western blotting in GC cells transfected with Vector and VAX2 (A1), Scr-siRNA and VAX2-siRNAp (A2), Control and LINC01189 (B1), or NC-siRNA and LINC01189-siRNAp (B2). C1/2 The average tumor/normal epithelium (T/N) expression ratios of VAX2, hnRNPF, and LINC01189 detected using western blotting (C1) or qPCR (C2) in 12 paired GC tissues. C, case. D1-3 Correlation between VAX2 and LINC001189 expression levels, between LINC01189 and hnRNPF expression levels, or between VAX2 and hnRNPF expression levels in 12 GC tissues. Correlation coefficient (r) and P-value were acquired by Pearson correlation. E IHC and ISH were carried out to determine VAX2, LINC01189, and hnRNPF expression patterns in human GC tissues and normal epithelium tissues. Scale bar: 100 µm. F Proposed functional action of VAX2-LINC01189-hnRNPF axis in modulating GC progression.