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Time dependence of [14C]sparfloxacin (40 μM) (a) and [3H]vinblastine (40 nM) (b) flux across Caco-2 cell monolayers. Apical-to-basal (•) and basal-to-apical (▾) transport were determined by measuring the level of accumulation of the radiolabelled drug in the contralateral compartment. Values are means ± SDs of three to five experiments.
