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. 1998 Oct;42(10):2607–2611. doi: 10.1128/aac.42.10.2607

TABLE 3.

Unidirectional (Jab and Jba) and net (Jnet) fluxes of [14C]sparfloxacin (40 μM) and [3H]vinblastine (40 nM) across Caco-2 cell monolayers and effect of the P-gp inhibitor verapamil on fluxesa

Inhibitor Jab Jba Jnet
Sparfloxacin (pmol · h−1 · cm−2) 376 ± 51 740 ± 55 −363 ± 43
Sparfloxacin + 100 μM verapamil 552 ± 89* 616 ± 74 −63 ± 15*
Vinblastine (fmol · h−1 · cm−2) 8 ± 1 126 ± 4 −118 ± 4
Vinblastine + 100 μM verapamil 44 ± 1* 98 ± 6* −54 ± 6*
a

Values are means ± SDs of three to five experiments. *, a statistically significant difference (P < 0.05) from the control flux.