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mRNA expression of the senescence-associated secretory phenotypes (SASPs); Timp1 (A–D), and Mmp12 (E–H) in the heart, liver, bone, kidney, and hypothalamus of SHR and WT rats at the age of 6, 12, 24 and 36 weeks. Results are presented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 compared with age-matched WT group. nd, not detected.
