Table 1.
Clinical characteristics of patients with cardiac paraganglioma
| Patient no. | Gender | Age at Dx (years) | Year of Dx | Presentation | Family history | Multiple PPGLs | Nonchromaffin tumors | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HTN | Headache | Palpitation | Perspiration | Chest pain | SOB | |||||||
| 1 | M | 16 | 2003 | + | + | − | − | − | − | − | − | − |
| 2 | M | 39 | 2003 | + | + | + | + | + | − | − | − | − |
| 3 | F | 35 | 2004 | + | + | + | + | − | − | − | HNPGLs | − |
| 4 | M | 22 | 2005 | + | + | + | + | − | − | − | − | − |
| 5 | M | 24 | 2007 | + | − | + | + | − | − | Metastatic PGL in 1 brother, PGL in daughter | Multiple CPGLs, bilateral PCCs, RPGLs | − |
| 6 | M | 49 | 2009 | + | − | − | − | − | − | − | HNPGL | papillary thyroid carcinoma, NSCLC |
| 7 | M | 44 | 2009 | + | − | − | − | − | − | Metastatic PCC in a first cousin, PGL in another first cousin | Multiple CPGLs, HNPGL, PCC, RPGL | pituitary microadenoma |
| 8 | M | 37 | 2010 | + | + | + | + | − | − | − | − | − |
| 9 | F | 48 | 2012 | + | + | − | + | − | − | − | − | − |
| 10 | F | 23 | 2012 | + | + | + | + | − | − | − | − | − |
| 11 | M | 11 | 2013 | + | − | + | + | − | − | − | − | − |
| 12 | M | 34 | 2014 | + | − | + | − | + | + | Metastatic PCC in 1 sister | HNPGL, RPGL | − |
| 13 | F | 50 | 2015 | + | − | + | − | − | − | − | − | − |
| 14 | F | 48 | 2015 | + | − | − | − | − | − | − | − | − |
| 15 | F | 32 | 2015 | − | − | − | − | − | − | − | HNPGLs | − |
| 16 | M | 48 | 2015 | + | + | + | + | − | − | − | HNPGLs, RPGL | − |
| 17 | M | 13 | 2015 | + | − | − | + | − | − | − | — | − |
| 18 | F | 21 | 2016 | + | + | − | − | − | − | − | RPGL | − |
| 19 | M | 44 | 2018 | + | + | + | − | − | − | − | RPGL, bladder PGL | − |
| 20 | M | 45 | 2019 | + | − | − | − | + | − | − | − | Pituitary microadenoma, chronic leukemia |
| 21 | M | 45 | 2019 | + | − | − | − | − | − | PPGLs in a first cousin once removed and a second cousin | Multiple CPGLs, bilateral PCCs | − |
| 22 | F | 32 | 2019 | − | − | − | − | + | − | − | − | Meningioma |
| 23 | M | 51 | 2020 | + | − | − | − | − | − | − | PCC, HNPGL, RPGL | − |
| 24 | M | 42 | 2021 | + | − | − | − | − | − | − | − | Thyroid nodule, pituitary microadenoma |
Abbreviations: CPGL, cardiac paraganglioma; Dx, diagnosis; F, female; HNPGL, head and neck paraganglioma; HTN, hypertension; M, male; NSCLC, nonsmall cell lung carcinoma; PCC, pheochromocytoma; PPGL, pheochromocytomas and paraganglioma; RGPL, retroperitoneal paraganglioma; SOB, shortness of breath.