Table 4.
Characteristics of cardiac paragangliomas in patients with or without germline SDHx mutation
| Germline mutation | |||
|---|---|---|---|
| SDHx (n = 13) | NI (n = 9) | P | |
| Gender, n (%) | |||
| Female | 3 (23) | 5 (56) | .187 |
| Age (median, range) | 34 (11-49) | 42 (13-50) | .471 |
| Presentation, n (%) | |||
| HTN | 11 (85) | 9 (100) | .494 |
| Headache | 5 (39) | 5 (56) | 0.666 |
| Palpitation | 8 (62) | 4 (44) | 0.666 |
| Perspiration | 6 (46) | 5 (56) | 1 |
| Chest pain | 3 (23) | 0 (0) | .24 |
| Multiple PPGLs, n (%) | 7 (54) | 3 (33) | .415 |
| Metastasis, n (%) | 1 (8) | 1 (11) | 1 |
| Family history, n (%) | 4 (31) | 0 (0) | .002 |
| Urinary CA elevationa, n (%) | |||
| Norepinephrine | 12 (100) | 8 (89) | .429 |
| Epinephrine | 2 (17) | 4 (44) | .331 |
| Dopamine | 8 (67) | 5 (56) | .673 |
| MTD (cm) (median, range) | 5.5 (3.5-8.0) | 5.0 (3.0-7.5) | .601 |
| Ki-67 index ≥ 3%a, n (%) | 5 (42) | 5 (56) | .67 |
Abbreviations: CA, catecholamine; HTN, hypertension; MTD, maximum tumor diameter; NI, not identified; PPGLs, pheochromocytomas and paragangliomas; SDHx, succinate dehydrogenase subunits.
a
Urinary CA and Ki-67 index were measured in 12 patients with SDHx mutation.