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. 2023 Jul 8;38(5):787–800. doi: 10.1016/j.virs.2023.07.003

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 4 — Broad-spectrum neutralization capability against authentic SARS-CoV-2. Neutralization antibody titers of aVHH-11-Fc, aVHH-13-Fc, and aVHH-14-Fc for SARS-CoV-2 BMA8, prototype, Delta, Omicron BA.1 and Omicron BA.2. Briefly, neutralization titer was detected by authentic SARS-CoV-2. Nbs were successively diluted dilution in a two-fold scale and 100 TCID₅₀ SARS-CoV-2 were added. Post incubation, cells were added. The maximum antibody dilution concentrations that neutralize all viral CPE were defined as the neutralizing titer. Statistical analysis was performed by two-way ANOVA, ∗P < 0.05. Data were presented as mean with standard deviation.