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Schematic diagram of the mechanism of EV-D68 antagonism of the antiviral effect of IFNβ. The structural protein of EV-D68 upregulates the expression of RFX7, a transcriptional regulator of SOCS3, leading to the upregulation of SOCS3 expression. This upregulation of SOCS3 inhibits the phosphorylation of STAT3, thereby inhibiting ISG expression.
