. 2023 Oct 17;65:102280. doi: 10.1016/j.eclinm.2023.102280

Table 2.

Global pooled incidence of AIH included in our systematic review.

	Number of studies	Number of participants	Pooled estimates (95% CI)^a	95% prediction interval	I² (%)	P value for I²	Egger's P value
Overall incidence	33	220,673,674	1.28 (1.01–1.63)	0.35–4.70	99.51	<0.0001	<0.001
Income
HDI >0.92	26	143,009,677	1.63 (1.28–2.07)	0.51–5.24	99.50	<0.0001	0.0040
HDI <0.92	4	12,898,869	0.73 (0.49–1.08)	0.17–3.12	49.28	0.12	0.59
Sex
Male	17	61,144,540	0.90 (0.65–1.24)	0.25–3.23	97.73	<0.0001	0.0090
Female	17	66,436,411	2.79 (2.14–3.64)	0.90–8.68	99.27	<0.0001	0.0050
Age group
Children	8	100,035,200	0.35 (0.24–0.52)	0.09–1.38	90.64	<0.0001	0.77
Adults aged under 65 years	17	87,144,548	1.45 (1.22–1.73)	0.55–3.83	98.51	<0.0001	<0.001
Adults aged over 65 years	8	14,770,970	3.59 (2.76–4.68)	1.04–12.36	97.51	<0.0001	<0.001
Geographical areas
North America	5	56,129,062	3.35 (2.71–4.13)	1.63–6.89	98.79	<0.0001	0.37
Europe	18	28,118,418	1.38 (1.18–1.61)	0.81–2.34	90.60	<0.0001	0.073
Asia	5	53,604,831	0.99 (0.60–1.64)	0.16–6.01	97.97	<0.0001	0.41
Oceania	3	1,558,288	1.90 (1.59–2.28)	0.58–6.20	0.00	0.70	0.60
Geographic latitude
Above 45°	21	89,490,232	1.83 (1.43–2.35)	0.60–5.54	99.51	<0.0001	0.013
Below 45°	9	66,874,557	0.93 (0.67–1.31)	0.32–2.71	87.72	<0.0001	0.48
Diagnostic scoring system for AIH^a
Before IAIHG	5	5,598,514	1.10 (0.85–1.41)	0.74–1.65	0.00	0.71	0.0070
Original IAIHG	2	697,685	1.03 (0.33–3.19)	NA	49.08	0.16	NA
Revised IAIHG	9	75,340,696	1.04 (0.52–2.09)	0.08–13.23	98.98	<0.0001	0.30
Simplified IAIHG	3	1,385,031	1.83 (0.72–4.69)	NA	81.51	0.0040	0.84
Data source
Researcher validated	20	15,415,852	1.29 (1.02–1.63)	0.51–3.25	90.41	<0.0001	0.011
Code-based	8	122,530,210	2.17 (1.48–3.17)	0.54–8.71	99.82	<0.0001	0.041
Type
Type I AIH	8	6,533,380	1.00 (0.55–1.82)	0.13–7.54	91.04	<0.0001	0.027
Type II AIH	8	96,780,945	0.03 (0.02–0.04)	0.02–0.04	0.00	0.70	0.65
Seronegative AIH	3	71,842,811	0.05 (0.00–0.83)	NA	91.21	<0.0001	0.61
Overlap syndrome
AIH-PBC	5	2,046,594	0.17 (0.09–0.32)	0.06–0.47	0.00	0.59	0.95
AIH-PSC	1	319,403	0.03 (0.00–0.22)	NA	NA	NA	NA
Score
Definite AIH	6	2,705,442	1.06 (0.49–2.30)	0.08–14.99	91.85	<0.0001	0.64
Probable and definite AIH	6	2,705,442	1.67 (0.95–2.95)	0.22–12.59	95.20	<0.0001	0.95

AIH, autoimmune hepatitis; HDI, human development index; IAIHG, international autoimmune hepatitis group; PBC, primary biliary cholangitis; PSC, primary sclerosing cholangitis; NA, not available.

These results were calculated and estimated using original data.