Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 9;14:1265914. doi: 10.3389/fimmu.2023.1265914

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Yan, Jiang, Huang, Zhang, Yang, Zhang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Exercise-Anti-PD-1 combined treatment alleviated TME hypoxia and improved the immune microenvironment with favorable biosafety. (A, B) Hypoxyprobe staining images (A) and IHC scores (B) of B16F10 tumor tissues in C57BL/6 mice with the specified treatments (scale bar: 100 μm, enlarged drawing: 50 μm; selected area: 5). (C–F) The detection of IFN-γ (C), Perforin (D) Granzyme B (E), and IL-10 (F) levels by ELISA in tumor tissues. (G–I) Weight (G) food intake (H) and water intake (I) of mice. (J, K) At the end of the experiment, using H&E to stain the liver (J) and kidney (K) from mice (scale bar: 100 μm). (L–N) Hepatotoxicity measured by aspartate aminotransferase (AST) (L), alanine aminotransferase (ALT) (M), and albumin (ALB) (N). (O, P) Nephrotoxicity measured by blood urea nitrogen (BUN) (O) and creatinine (Crea) (P). (Q) The schematic diagram of tumor reaction process after MS and Anti-PD-1 combination treatment. The data were presented as mean ± s.d. Statistical significance of the differences between groups was determined using t test. *, p<0.05; **, p<0.01; ***, p<0.001.