TABLE 4.
Expressions of markers of steroidogenesis in the testis and testicular cells of rats and mice after atrazine exposure as reported in literature.
| Parameter | Cell types/tissue | Concentrations/doses | Expressions | References |
|---|---|---|---|---|
| 3β-HSD | Testis | >50 mg/kg | Decreased | Victor-Costa et al. (2010) |
| 3β-HSD | Leydig cells | 5–50 μg/mL | Increased | Abarikwu et al. (2012) |
| AR | Sertoli-germ cells | 50 μg/mL | Increased | Abarikwu et al. (2012) |
| ER-alpha | Sertoli-germ cells | 50 μg/mL | No change | Abarikwu et al. (2012) |
| ER-alpha | Leydig cells | 10 μg/mL | Increased | Abarikwu et al. (2011a) |
| SCF | Sertoli-germ cells | 50 μg/mL | Decreased | Abarikwu et al. (2012) |
| CYP11A1 | Leydig cells | 5–10 μg/mL | Increased | Abarikwu et al. (2011a) |
| StAR | Leydig cells | 5–10 μg/mL | Increased | Abarikwu et al. (2011a) |
| LHR | Testis | 50–200 mg/kg | Decreased | Pogrmic et al. (2009) |
| 17β-HSD | Testis | 50–200 mg/kg | Decreased | Pogrmic et al. (2009) |
| StAR | Testis | 50–200 mg/kg | Decreased | Pogrmic et al. (2009) |
| CYP17A1 | Testis | 50–200 mg/kg | Decreased | Pogrmic et al. (2009) |
| SR-B1 | Testis | 50–200 mg/kg | Decreased | Pogrmic et al. (2009) |
| 17β-HSD | Leydig cells | 20 μM | Increased | Pogrmic et al. (2009) |
| CYP-17A1 | Leydig cells | 20 μM | Increased | Pogrmic et al. (2009) |
| SF-1 | Leydig cells | 20 μM | Increased | Pogrmic et al. (2009) |
| StAR | Leydig cells | 20 μM | Increased | Pogrmic et al. (2009) |
| 3β-HSD | Testis | 50 mg/kg | Decreased | Abarikwu et al. (2021) |
| ARO | Testis | 50 mg/kg | Decreased | Abarikwu et al. (2021) |
| AR | Testis | 50 mg/kg | Increased | Abarikwu et al. (2021) |
| ER-α | Testis | 50 mg/kg | Increased | Abarikwu et al. (2021) |
| p450scc | Testis | 100–200 mg/kg | Decreased | Jin et al. (2013) |
| p450 17α1 | Testis | 100–200 mg/kg | Decreased | Jin et al. (2013) |
| 17β-HSD | Testis | 100–200 mg/kg | Decreased | Jin et al. (2013) |
| SR-B1 | Testis | 200 mg/kg b.w | Decreased | Jin et al. (2014) |
3 β-HSD, 3β-Hydroxysteroid steroid dehydrogenase; AR, androgen receptor; ER-alpha = estrogen receptor-alpha; SCF, stem cell factor; CYP11A1 = cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc); StAR, steroidogenic acute regulatory protein; CYP17A1 = cytochrome P450 17α-hydroxysteroid dehydrogenase (P450 17α); SF-1, steroidogenic factor-1; ARO, aromatase; scavenger receptor class B type 1 (SR-B1); 17β-HSD, 17β-Hydroxysteroid dehydrogenases.