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. 2023 Oct 6;4(10):101201. doi: 10.1016/j.xcrm.2023.101201

Figure 1.

Figure 1

SIV challenge virus switching Envs during the first round of replication

(A) Scheme of concept. Replication of an SIV challenge virus using HIV-1 Env for the first, but SIV Env for subsequent rounds of infections (upper half). If a neutralizing antibody (lower half) to HIV-1 Env prevents infection it can only do so by blocking the first infection event, since SIV Env is not targeted by the antibody.

(B) Map of SIVdup and assumed mechanism of repair during reverse transcription (RT). The inactivated SIV env with the internal direct tandem repeat (ennv) is shaded.