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. 2023 Sep 26;4(10):101209. doi: 10.1016/j.xcrm.2023.101209

Figure 5.

Figure 5

tRF-3001a regulates diabetes-induced visual impairment in vivo

Vision-related behavioral tests were used to evaluate the degree of visual impairment in non-diabetic mice (Ctrl), STZ-induced diabetic mice (WT), or STZ-induced diabetic mice injected with negative control (NC) agomir, tRF-3001a agomir, NC antagomir, or tRF-3001a antagomir at 6 months after diabetes induction. The schematic diagram for visual cliff test is shown (A). The statistical results display the number (left y axis) and percentage (right y axis) of cliff/safe side choosers (B, n = 6). The schematic diagram of dark-light preference test is shown (C). The statistical result shows the percentage of time in the dark chamber within 5 min (D, n = 6). The schematic diagram of Morris water maze test is shown (E). The statistical result shows the time required until the mice reached the visible platform for 8 days (F, n = 6). ∗p < 0.05 between the marked groups. The significant difference was evaluated by one-way ANOVA followed by post hoc Bonferroni test. See also Figure S9.