Figure 4.
Heterogeneity and evidence for metastasis in tumors from CAG-A3B animals
(A and B) Representative healthy intestine with Peyer’s patch (arrow) and healthy liver tissues, respectively, from CAG-A3B mice.
(C and D) Macroscopic pictures of a heterogeneous assortment of lymphomas and HCCs, respectively, from CAG-A3B mice.
(E) Representative image of a primary HCC that metastasized to the lung (HCC B from CAG-A3B #13 in D).
(F) H&E, anti-A3B, and anti-B220 IHC of lymphoma B from CAG-A3B #12. Inset boxes show portions of the same tumors at 4× additional magnification.
(G) H&E and anti-A3B IHC of HCC from CAG-A3B #2. Inset boxes show portions of the same tumors at 4× additional magnification.
(H) H&E and anti-A3B IHC staining of a primary HCC (top) and its metastatic dissemination to the lung (bottom) from CAG-A3B #13. Inset boxes show portions of the same tumors at 4× additional magnification.
(I) H&E and anti-A3B IHC staining of a diffuse large B cell lymphoma in the liver (left) and kidney (right). Inset boxes show the same tumors at 4× additional magnification.