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. 2023 Oct 4;4(10):101211. doi: 10.1016/j.xcrm.2023.101211

Figure 6.

Figure 6

DNA deaminase activity is required for A3B-driven tumor phenotypes

(A) Anti-A3B IHC staining of representative tissues from CAG-A3B-E255A mice (40× magnifications on right are enlargements of regions of the corresponding 10× images on left).

(B) Kaplan-Meier curves comparing tumor-free survival of WT (n = 27), CAG-A3B (n = 16), and CAG-A3B-E255A (n = 24) mice (log rank Mantel-Cox test p values indicated). The number of animals with tumors is shown over the total number of animals in each group. Vertical lines on each curve indicate mice that were censored.

(C) Dot plot of the number of tumors per mouse in each respective genotype (mean ± SEM; Mann-Whitney U test p values indicated).

(D) Pie chart summarizing tumor locations in CAG-A3B and CAG-A3B-E255A mice.

(E) Representative SBS mutation profiles for the indicated tumors from CAG-A3B and CAG-A3B-E255A animals (mutation numbers shown). The dashed box highlights APOBEC3-preferred TC motifs characteristic of SBS2.

See also Figure S6.