Figure 7.

Hypermutated CAG-A3B tumors also exhibit higher frequencies of a range of structural variations

(A) Composite spectrum of the average number of small indels in tumors from WT (n = 9) and CAG-A3B (n = 29) animals.

(B–K) Scatterplots showing relationships between APOBEC mutation signature enrichment scores from CAG-A3B tumors and the indicated indel types (linear regression lines, except F–I, and Spearman’s rank correlation coefficients and corresponding p values indicated).

(L) Scatterplot showing the relationship between APOBEC mutation signature enrichment scores from CAG-A3B tumors and the total number of indels <200 bp in each tumor (linear regression line and Spearman’s rank correlation coefficient and corresponding p value indicated).

(M) Violin plots of the total number of structural variations in tumors from WT mice in comparison with tumors from CAG-A3B animals with low or high APOBEC mutation signature enrichment scores (ES; Mann-Whitney U test p values indicated).

See also Figure S7.