REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
anti-Mouse CD11c APC, clone N418	eBioscience	Catalog#:17-0114-82; RRID: AB_469346
anti-Mouse CD86 eFluor 450, clone GL1	eBioscience	Catalog#: 48-0862-82; RRID: AB_2574031
anti-Mouse CD83 PE, clone Michel-17	eBioscience	Catalog#: 12-0831-82; RRID: AB_465758
anti-Mouse MHC II APC eFluor 780, clone M5/114.15.2	eBioscience	Catalog#: 47-5321-82; RRID: AB_1548783
anti-Mouse OVA257-264 (SIINFEKL) peptide bound to H-2Kb APC, clone eBio25-D1.16	eBioscience	Catalog#: 17-5743-80; RRID: AB_1311288
anti-Mouse CD45 eFluor 450, clone 30-F11	eBioscience	Catalog#: 48-0451-82; RRID: AB_1518806
anti-Mouse CD3 PE-Cyanine 5.5, clone 145-2C11	eBioscience	Catalog#: 35-0031-82; RRID: AB_11219266
anti-Mouse CD8 PE, clone 53-6.7	eBioscience	Catalog#: 12-0081-82; RRID: AB_465530
anti-Mouse CD4 APC, clone RM4-5	eBioscience	Catalog#: 17-0042-82; RRID: AB_469323
anti-Mouse CD44 Super Bright 645, clone IM7	eBioscience	Catalog#: 64-0441-82; RRID: AB_2662590
anti-Mouse CD69 PE Cyanine 7, clone H1.2F3	eBioscience	Catalog#：25-0691-82; RRID: AB_469637
anti-Mouse CD33 PE, clone 9A11-CD33	eBioscience	Catalog#：12-0331-82; RRID: AB_2637179
anti-Mouse PIR-A/B APC, clone 10-1-PIR	eBioscience	Catalog#：17-3101-82; RRID: AB_1944406
anti-Mouse PD-1 APC, clone RMP1-30	eBioscience	Catalog#：17-9981-82; RRID: AB_10852564
anti-Mouse TIM-3 PE, clone RMT3-23	eBioscience	Catalog#：12-5870-82; RRID: AB_465974
anti-Mouse CD11b FITC, clone M1/70	eBioscience	Catalog#：11-0112-81; RRID: AB_464934
anti-Mouse CD16/CD32 Monoclonal, Clone 2.4G2, clone	BD	Catalog#: 553141; RRID: AB_394656
anti-Mouse CTLA-4 PE,clone UC10-4F10-11	BD	Catalog#: 553720; RRID: AB_395005
anti-Mouse CD3 PerCP-Cy™5.5, clone 145-2C11	BD	Catalog#: 551163; RRID: AB_394082
anti-Mouse CD8 Alexa Fluor 700, clone 53-6.7	BD	Catalog#: 557959; RRID: AB_396959
anti-Mouse CD4 BV510, clone GK1.5	BD	Catalog#: 743155; RRID: AB_2741308
anti-Mouse CD62L FITC, clone MEL-14	BD	Catalog#: 561917; RRID: AB_10893197
anti-Mouse CD44 BV650, clone IM7	BD	Catalog#: 740455; RRID: AB_2740182
anti-Mouse PD-1 PE, clone J43	BD	Catalog#: 551892; RRID: AB_394284
anti-Mouse CD274 PE, clone MIH5	BD	Catalog#: 558091; RRID: AB_397018
anti-Mouse CD25 APC, clone PC61	BD	Catalog#: 557192; RRID: AB_398623
anti-Mouse Foxp3 PE, clone R16-715	BD	Catalog#: 563101; RRID: AB_2738006
anti-Human CD11c BV421, clone B-ly6	BD	Catalog#: 562561; RRID: AB_2737656
anti-Human CD86 APC, clone 2331 (FUN-1)	BD	Catalog#: 555660; RRID: AB_398608
anti-Human MHC II PE, clone G46-6	BD	Catalog#: 555812; RRID: AB_396146
anti-Human CD47 PE, clone B6H12	BD	Catalog#: 556046; RRID: AB_396317
anti-Mouse CD11c PE Cyanine7, clone N418	BioLegend	Catalog#: 117318; RRID: AB_493568
anti-Mouse SIRPα Alexa Fluor 700, clone P84	BioLegend	Catalog#: 144022; RRID: AB_2650813
anti-Mouse CD103 PE Cyanine7, clone 2E7	BioLegend	Catalog#: 121425; RRID: AB_2563690
anti-Mouse CD47 PE,clone miap301	BioLegend	Catalog#: 127508; RRID: AB_1134117
InVivoMAb rat IgG2b isotype control, clone LTF-2	Bio X cell	Catalog#: BE0090; RRID: AB_1107780
InVivoMAb anti-mouse PD-L1, clone 10F.9G2™	Bio X cell	Catalog#: BE0101; RRID: AB_10949073
Rat IgG2b isotype control-InVivo, clone LTF-2	Selleck	Catalog#: A2116; RRID: AB 1107780
Anti-mouse CD4-InVivo, clone GK1.5	Selleck	Catalog#: A2101; RRID: AB_1107636
Anti-mouse CD8-InVivo, clone GK2.43	Selleck	Catalog#: A2102; RRID: AB_1125541
DAP12 (D7G1X) Rabbit mAb	CST	Catalog#: 12492
Syk (D3Z1E) XP® Rabbit mAb	CST	Catalog#: 13198
Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb	CST	Catalog#: 2710
PLCγ1 (D9H10) XP® Rabbit mAb	CST	Catalog#: 5690
PLCγ2 (E5U4T) Rabbit mAb	CST	Catalog#: 55512
Phospho-PLCγ2 (Tyr759) (E9E9Y) Rabbit mAb	CST	Catalog#: 50535
GAPDH (14C10) Rabbit mAb	CST	Catalog#: 2118
Phospho-PLCγ1 (Tyr783) (D6M9S) Rabbit mAb	CST	Catalog#: 14008
Chemicals, peptides, and recombinant proteins
Recombinant Murine GM-CSF	PeproTech	Catalog#: 315-03-250
Recombinant Murine IL-4	PeproTech	Catalog#: 214-14-100
Ovalbumin	Ovalbumin	Catalog#: A7641
LPS	LPS	Catalog#: tlrl-rslps
Critical commercial assays
Fixable Viability Stain 510	BD	Catalog#: 564406
Fixable Viability Stain 780	BD	Catalog#: 565388
Transcription Factor Staining Buffer Set	BD	Catalog#: 562574
EasySepTM mouse CD11c positive selection kit	STEMCELL Technologies	Catalog#: 18780
EasySepTM mouse T cell negative isolation kit	STEMCELL Technologies	Catalog#: 19851
EasySepTM mouse naïve CD8+ T cell negative isolation kit	STEMCELL Technologies	Catalog#: 19858
Mouse tumor lymphocyte infiltration kit	Solarbio	Catalog#: P9000
RBC Lysis Buffer	TIAN GEN	Catalog#: RT122
Mouse TNF-α ELISA Research Reagent Kit	4A Biotech	Catalog#: CME0004
Mouse IL-6 ELISA Research Reagent Kit	4A Biotech	Catalog#: CME0006
Mouse IFN-β ELISA Research Reagent Kit	4A Biotech	Catalog#: CME0116
Mouse TNF-α ELISA Research Reagent Kit	Jingmei Biotech	Catalog#: 02415M1
Mouse IL-12 ELISA Research Reagent Kit	Jingmei Biotech	Catalog#: 11506M1, 11386M1
Mouse granzyme B ELISA Research Reagent Kit	Multi Sciences	Catalog#: EK2173-96
Mouse IFN-γ ELISA Research Reagent Kit	Multi Sciences	Catalog#: EK280/3-96
Mouse perforin ELISA Research Reagent Kit	Elabscience	Catalog#: E-EL-M0890c
RevertAid Reverse Transcriptase	Thermo Fisher	Catalog#: EP0441
Super Real Pre Mix SYBR Green	Tiangen	Catalog#: FP204-02
Deposited data
RNA seq dataset	This paper	GEO: GSE222080
Experimental models: Cell lines
B16-F10	Cellcook Biotech	Catalog#: CC9016
CT-26	Cellcook Biotech	Catalog#: CC9036
RM-1	Cellcook Biotech	Catalog#: CC9004
Pan02	Provided by Virotech Co., Ltd.	Catalog#: N/A
HCT-8	ATCC	Catalog#: CCL-244
HCT-116	National Collection of Authenticated Cell Cultures	Catalog#: TCHu 99
SW-620	National Collection of Authenticated Cell Cultures	Catalog#: TCHu101
Human-derived BMDCs	ORiCells Biotech	Catalog#: PB-DC001F-C, PB-DC002F-C
Experimental models: Organisms/strains
C57BL/6J	Guangdong Medical Laboratory Animal Center	Catalog#: GDMLAC-019
C57BL/6J	Guang Dong GemPharmatech Co., Ltd.	Catalog#: N000013
Balb/c	Guang Dong GemPharmatech Co., Ltd.	Catalog#: N000020
SIRPα-KO C57	Provided by Prof. Jun Chen	N/A
OT-I C57	Provided by Virotech Co., Ltd.	N/A
Batf3-KO C57	Provided by Prof. Cliff Yang	N/A
Oligonucleotides
CD47 EasyEdit sgRNA	GenScript	CCCTTGCATCGTCCGTAATG
primer	Genewiz	Table S1 for detailed sequence information
Software and algorithms
ImageJ	Image.sc	https://imagej.net/ij/index.html
Flowjo	BD	https://www.flowjo.com
Grahpad Prism (v9)	Dotmatics	https://www.graphpad.com
R	The R Foundation	https://www.r-project.org
CytExpert	Beckman Coutler	N/A
Adobe Illustrator	Adobe	https://www.adobe.com