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. 2023 Oct 9;13:1256769. doi: 10.3389/fonc.2023.1256769

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Copyright © 2023 León-Letelier, Dou, Vykoukal, Sater, Ostrin, Hanash and Fahrmann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Created with BioRender.com. Schematic of the KP, Kynurenine Pathway; AFMID, arylformamidase; HAAO, 3-hydroxyanthranilate 3,4-dioxygenase; IDO1, indoleamine 2,3-dioxygenase 1; IDO2, indoleamine 2,3-dioxygenase 2; KAT, kynurenine aminotransferase; KMO, kynurenine 3-monooxygenase; KYNU, kynureninase; NAD+, nicotinamide adenine dinucleotide; TDO2, tryptophan 2,3-dioxygenase; QPTR, quinolinic acid phosphoribosyl transferase.