Table 3.
Cox proportional hazard models
| Variable | Univariable analysis |
Multivariable analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Medical treatment vs TAVR, age ≥ 90 y | 2.27 (1.57–3.26) | < 0.001 | 1.99 (1.37–2.88) | < 0.001 |
| Age, increment 2 y | 1.29 (1.10–1.52) | 0.002 | 1.32 (1.10–1.57) | 0.002 |
| Female sex | 0.92 (0.64–1.32) | 0.64 | 0.98 (0.67–1.42) | 0.90 |
| NYHA class III/IV vs I/II | 1.34 (0.89–2.00) | 0.16 | — | — |
| History of stroke/TIA | 1.26 (0.81–1.96) | 0.30 | — | — |
| Dyslipidemia | 1.26 (0.86–1.85) | 0.23 | — | — |
| Diabetes | 1.75 (1.14–2.69) | 0.011 | 2.06 (1.29–3.29) | 0.003 |
| Arterial hypertension | 1.61 (1.03–2.52) | 0.038 | 1.89 (1.17–3.03) | 0.009 |
| COPD | 1.41 (0.88–2.26) | 0.16 | — | — |
| Coronary artery disease | 1.07 (0.73–1.54) | 0.75 | — | — |
| Atrial fibrillation/flutter | 0.94 (0.65–1.36) | 0.73 | — | — |
| Creatinine clearance < 60 mL/min | 0.86 (0.43–2.01) | 0.86 | — | — |
| Carotid stenosis | 0.83 (0.39–1.80) | 0.64 | — | — |
| SPAP, increment 5 mm Hg | 0.96 (0.90–1.02) | 0.20 | — | — |
Text in bold highlights the statistically significant associations.
CI, confidence interval; COPD, chronic obstructive pulmonary disease; HR, hazard ratio; NYHA, New York Heart Association; SPAP, systolic pulmonary artery pressure; TAVR, transcatheter aortic valve replacement; TIA, transient ischemic attack.