Fig. 1.

(A) Administration with Lamotrigine (300 mg) provided a reduction in neuroplasticity in the human motor cortex. (B) In wild- type mice, administration with dia-zepam (30 mg/kg) provided a reduc-tion in transcript expression levels related to the neuroplastic effect, however, in α1 (H101R) mutated animals, these changes were not observed. (C) Levetiracetam (40 mg/kg) administration enabled an increase in BDNF expression in the rat hippo-campus. (D) Valproic acid (400 mg/kg) treatment in BSN mutant mice made it possible to restore synaptic neuro-plasticity in the striatum.

BDNF, brain-derived neurotrophic factor; MAP, mitogen activated protein; BSN, bassoon.