Fig. 2.

(A) Prenatal stage mice were treated with VPA. Prenatal exposure to this drug promoted increased levels of susceptibility to seizures, reduced expression of Cxcr4, and induction of aberrant neurogenesis in GD. (B) A study carried out in Xenopus treated with VPA, showed that the application of this drug promoted increased H3K9 acety-lation and increased GABA cells in the optic roof, and gene expression linked to elevated GABAergic neuro-genesis.

VPA, valproic acid; GD, gyrus dentatus; GABA, γ-aminobutyric acid.