Fig. 3.

(A) Wild-type mice and mice lacking the presynaptic protein Bassoon were treated with 400 mg/kg of Valproic Acid. The treatment provided a reduction in seizures, and ortality, rescued hippocampal LTP, and promoted changes in hippocampal functions. (B) Rats were treated with 300 mg/kg of Valproic Acid. There was a reduction in cell proliferation in the dentate gyrus, in addition to a reduction in the levels of BDNF and Notch1. (C) The effect of levetiracetam (54 mg/kg) was evaluated on hippocampal synaptic neuroplasticity in rat CA3-CA1 regions. Treatment with this drug promoted the reestablishment of basal synaptic transmission, furthermore, this drug did not affect hippocampal neurogenesis. (D) Rats were treated with 300 mg/kg Levetiracetam. Treatment with this drug was not able to restore synaptic neuroplasticity in the dentate gyrus region of the hippocampus of these animals.

LTP, Long-Term Potentiation; BDNF, brain-derived neurotrophic factor.