TABLE 3.

Comparison of total cytochrome P-450 content and fluconazole susceptibility of 14α-demethylases of C. albicans and C. krusei^a

Organism	Fluconazole IC50 (μM)b	Cytochrome P-450 content (nmol/mg of protein)
C. albicans Y01.345	0.017 ± 0.005	0.077 ± 0.037
C. albicans SC5314	0.032 ± 0.006	0.058 ± 0.037
C. krusei 91-1158	0.751 ± 0.384	0.052 ± 0.021
C. krusei 91-1159	0.495 ± 0.208	0.065 ± 0.018
C. krusei 91-1161	0.795 ± 0.436	0.077 ± 0.060

^aResults are the means ± standard deviations of at least three separate measurements. 

^bConcentration of fluconazole required to inhibit the synthesis of ergosterol from [¹⁴C]mevalonic acid by 50%.