Table 5.
Multivariable Logistic Regression Models. (A) Model for Dialysis Following Heart Transplant. (B) Model for Nonrecoverable, Chronic Dialysis Requirement Among Recipients With Post-Transplant Renal Failure Requiring Dialysis
| A. | |||
|---|---|---|---|
| Odds ratio | 95% confidence interval | p-value | |
| BMI, increasing per 1 kg/m2 | 1.04 | 1.03, 1.06 | <0.001 |
| Recipient blood type | |||
| A | Ref | Ref | Ref |
| AB | 1.21 | 0.85, 1.73 | 0.292 |
| B | 0.76 | 0.59. 0.98 | 0.037 |
| O | 0.91 | 0.76, 1.09 | 0.294 |
| Heart failure etiology | |||
| Nonischemic | Ref | Ref | Ref |
| Ischemic | 0.92 | 0.76, 1.12 | 0.426 |
| Congenital | 2.59 | 1.82, 3.68 | <0.001 |
| Restrictive | 1.52 | 1.05. 2.20 | 0.026 |
| Valvular | 2.02 | 1.04, 3.93 | 0.038 |
| Hypertrophic | 1.32 | 0.15, 11.74 | 0.806 |
| Previous sternotomy and/or cardiac surgery | 1.27 | 1.07, 1.51 | 0.007 |
| Total bilirubin, increasing, per 1 mg/dL | 1.09 | 1.04, 1.13 | <0.001 |
| eGFR at transplant, mL/min/1.73 m2 | |||
| ≥90 | Ref | Ref | Ref |
| 60-89 | 1.76 | 1.33, 2.32 | <0.001 |
| 30-59 | 2.82 | 2.15, 3.70 | <0.001 |
| 15-29 | 4.57 | 2.75, 7.61 | <0.001 |
| <15 | 16.51 | 3.51, 77.65 | <0.001 |
| Mechanically ventilated at time of transplant | 1.85 | 1.13, 3.06 | 0.015 |
| Blood transfusion on waitlist | 1.45 | 1.16, 1.80 | 0.001 |
| Pretransplant ECMO | 1.82 | 1.27, 2.60 | 0.001 |
| Sex-matched donor and recipient | 1.17 | 0.95, 1.43 | 0.131 |
| Race-matched donor and recipient | 1.12 | 0.95, 1.32 | 0.161 |
| Graft cold ischemia time, increasing, per hour | 1.11 | 1.03, 1.19 | 0.007 |
| Induction regimen | |||
| ATGAM | Ref | Ref | Ref |
| Thymoglobulin | 0.64 | 0.39, 1.05 | 0.077 |
| Basiliximab | 0.69 | 0.42, 1.12 | 0.132 |
| Steroids only | 0.47 | 0.29, 0.78 | 0.003 |
| Other | 0.65 | 0.34, 1.27 | 0.211 |
| Initial tacrolimus maintenance immunosuppression | 0.36 | 0.25, 0.47 | <0.001 |
| Initial mycophenolate mofetil maintenance immunosuppression | 0.83 | 0.65, 1.06 | 0.130 |
| 1,737 (24%) of study patients were excluded from the final model due to incomplete data. | |||
| B. | |||
| Odds ratio | 95% confidence interval | p-value | |
| BMI, increasing per 1 kg/m2 | 1.03 | 0.99, 1.07 | 0.179 |
| Previous sternotomy and/or cardiac surgery | 1.96 | 1.32, 2.90 | 0.001 |
| eGFR at transplant, mL/min/1.73 m2 | |||
| ≥90 | Ref | Ref | Ref |
| 60-89 | 1.75 | 0.77, 3.95 | 0.180 |
| 30-59 | 1.54 | 0.69, 3.42 | 0.293 |
| 15-29 | 2.69 | 0.95, 7.63 | 0.063 |
| <15 | 7.68 | 1.77, 33.28 | 0.006 |
| IABP at time of transplant | 0.69 | 0.43, 1.10 | 0.118 |
| Female donor | 1.48 | 0.99, 2.22 | 0.059 |
| ABO-matched donor and recipient | 0.49 | 0.31, 0.78 | 0.003 |
| Race-matched donor and recipient | 0.71 | 0.48, 1.03 | 0.071 |
| Mycophenolic acid as initial maintenance immunosuppression | 0.59 | 0.28, 1.26 | 0.173 |
| Cyclosporin as initial maintenance immunosuppression | 2.57 | 0.95, 6.92 | 0.062 |
Abbreviations: BMI, body mass index; ECMO, extracorporeal membrane oxygenation; eGFR, estimated glomerular filtration rate; IABP, intra-aortic balloon pump.
No study patients were excluded from the final model due to incomplete data.