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. Author manuscript; available in PMC: 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Jul 22;42(8):112830. doi: 10.1016/j.celrep.2023.112830

Figure 3. MycKO mice have extended lifespans and lower cancer incidence.

Figure 3.

(A) Natural lifespans of WT and MycKO male, female, and all mice.

(B) Incidence of associated gross pathologies in WT and MycKO mice at the time of demise.

(C) High-grade lymphoma from a MycKO mouse forming a nodular mass adjacent to a loop of bowel.

(D) Well-differentiated MycKO colonic adenocarcinoma.

(E) High-grade MycKO lymphoma replacing normal liver parenchyma.

(F) Probable MycKO plasmacytoma.

(G) Splenic MycKO lymphoma.

(H) Lymphoma from the mouse in (G) effacing a lymph node adjacent to the pleural surface.

(I) Myc protein expression. Control tissues included normal liver and a hepatoblastoma.55 Lymphomas from three MycKO mice (#1 to #3) were sampled from the two indicated sites.

(J) Myc alleles in MycKO lymphomas (I). Myc copy number quantification was performed on several sections of each tumor (Figure S1). DNAs from WT and MycKO primary MEFs (n = 4 each) served as controls for two copies or zero copies, respectively, of an intact Myc allele.23 (A) Log rank test; (B) unpaired t test, **p < 0.01, ***p < 0.001, ****p < 0.0001; ns, not significant; (J) error bars: SD.