Table 2.

Hazard Ratio of APOE Genotype from Cox Proportional Hazards Model

	AD Cohort (N = 2,007)				MCI Cohort (N = 1,480)
	Unadjusted Model		Adjusted Model*		Unadjusted Model		Adjusted Model*
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
ε2/ε3 (Reference group)
ε2 (ε2/ε2 & ε2/ε3)	0.66 (0.40, 1.09)	0.103	0.75 (0.45, 1.24)	0.262	0.90 (0.65, 1.24)	0.529	0.88 (0.63, 1.21)	0.427
ε4 (ε3/ε4 & ε4/ε4)	1.99 (1.50, 2.66)	< 0.0001	2.04 (1.52, 2.73)	< 0.0001	1.38 (1.09, 1.75)	0.009	1.40 (1.10, 1.78)	0.006
ε2/ε4	0.74 (0.34, 1.61)	0.453	0.85 (0.39, 1.84)	0.679	0.92 (0.54, 1.57)	0.763	0.88 (0.51, 1.50)	0.637
ε2/ε4 compared to other genotypes as reference group
ε2/ε4 versus ε2	1.13 (0.47, 2.68)	0.787	1.13 (0.47, 2.70)	0.78	1.02 (0.57, 1.82)	0.94	1.00 (0.56, 1.79)	0.991
ε2/ε4 versus ε4	0.37 (0.17, 0.80)	0.011	0.42 (0.19, 0.90)	0.026	0.67 (0.39, 1.14)	0.141	0.63 (0.37, 1.08)	0.091

^*Models were adjusted for age, sex, education, baseline cognitive status, and year of initial visit.