Figure 1.

Schematic of neocortical development. The development of the cortex begins at the ventricular zone (VZ) for excitatory projection neurons and at the ganglionic eminences for inhibitory interneurons. Both progenitor populations undergo multiple rounds of proliferation before differentiating into neurons and migrating into the cortical plate, where they integrate into functional circuitry. (For additional details, see sidebar Overview of Neuronal Development.) Abbreviations: SP, subplate; SVZ, subventricular zone. Adapted from Greig et al. (48) with permission.