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. Author manuscript; available in PMC: 2023 Oct 23.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2014;15:195–213. doi: 10.1146/annurev-genom-090413-025600

Figure 2.

Figure 2

Schematic showing how neurodevelopmental disorder mutations affect genes that function at different stages of neurodevelopment. Defects in the proliferation of progenitors in the ventricular zone or the cortex can lead to microcephaly or hemimegalencephaly, respectively. Defects affecting the migration of neurons from the ventricular zone to the cortex give rise to lissencephaly. Connectivity defects are thought to underlie autism, intellectual disability, and neuropsychiatric disorders.