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. 2023 Jul 13;3(5):371–388. doi: 10.1021/acsbiomedchemau.3c00026

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© 2023 The Author. Published by American Chemical Society

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(A) Biosynthetic pathway of bottromycin A2 (115). The thiazol(in)e ring involved in BotCYP-catalyzed decarboxylation is highlighted in blue. (B) Proposed biosynthetic pathway of mechercharmycins (119, 120) and chemical structures of other polyazole cyclopeptides (121–124). McmI is assumed for the leader and follower peptides dependent β-hydroxylation at Phe. (C) Chemical structures of pheganomycins (126–129). Pgm7 is deduced for the hydroxylation of the methyl group. For (B) and (C), the proposed hydroxylations catalyzed by P450s are highlighted in blue.