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(A) SchY catalyzes an epoxidation to generate intermediate 41, which is further rearranged to form the imidazopiperidine moiety in the biosynthesis of Sch40832 (46). (B) TsrR and TsrP are involved in the biosynthesis of thiostrepton (50) for dihydroxylation at Ile10 and epoxidation of quinaldic acid moiety, respectively. (C) Chemical structures of other dihydroxylation containing thiopeptides (51–55). The moieties formed by P450s are highlighted in blue.
