Table 2.

The most detrimental and protective factors for the three thyroid diseases.

Trait	Exposure	IVW		MR-Egger		Weighted median
		OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Thyroid cancer	Aspartate	7.41(1.51-36.27)	0.013	89.24(1.01-7882.92)	0.188	6.67(0.80-55.52)	0.079
Thyroid cancer	C-glycosyltryptophan	0.04(0.00-0.29)	0.001	0.02(0.00-14.33)	0.261	0.04(0.00-0.88)	0.041
Graves’ disease	Kynurenine	2.69(1.08-6.66)	0.033	2.10(0.21-21.28)	0.533	1.05(0.26-4.19)	0.945
Graves’ disease	4-androsten-3beta,17beta-diol disulfate 2	0.48(0.25-0.91)	0.024	0.17(0.02-1.53)	0.133	0.40(0.17-0.94)	0.036
Hashimoto thyroiditis	Alpha-ketoglutarate	46.89(4.65-473.28)	0.001	74.02(0.00-875286845)	0.617	11.17(0.46-268.59)	0.137
Hashimoto thyroiditis	X-14189–leucylalanine	0.31(0.15-0.64)	0.001	0.40(0.11-1.50)	0.209	0.34(0.13-0.92)	0.033

IVW, inverse variance weighted.