Table 3.
Effect of thyroid disease on metabolites.
| Outcome | Exposure | N | IVW | Heterogeneity | Pleiotropy | Steiger direction | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR(95%CI) | P | IVW Q | P | Intercept | P | correct_causal_direction | steiger_pval | |||
| Glutamine | Thyroid cancer | 4 | 1.00(0.99-1.00) | 0.017 | 0.469 | 0.926 | -0.0007116 | 0.745 | TRUE | 0.323031496 |
| Ornithine | Thyroid cancer | 4 | 0.99(0.98-1.00) | 0.036 | 1.687 | 0.640 | 0.0046533 | 0.375 | TRUE | 0.605736847 |
| 5-oxoproline | Thyroid cancer | 4 | 0.99(0.99-1.00) | 0.037 | 3.150 | 0.369 | -0.0034355 | 0.315 | TRUE | 0.780286918 |
| X-12095–N1-methyl-3-pyridone-4-carboxamide | Thyroid cancer | 4 | 1.01(1.00-1.02) | 0.022 | 0.171 | 0.982 | 0.0011305 | 0.835 | TRUE | 0.409721711 |
| Taurolithocholate 3-sulfate | Thyroid cancer | 4 | 0.98(0.96-1.00) | 0.009 | 0.593 | 0.898 | 0.0058003 | 0.637 | TRUE | 0.777404811 |
| Glutamine | Graves’ disease | 11 | 1.00(0.99-1.00) | 0.028 | 5.464 | 0.858 | -0.000132 | 0.896 | TRUE | 0.480345297 |
| Stearate (18:0) | Graves’ disease | 11 | 1.00(1.00-1.01) | 0.049 | 6.283 | 0.791 | 0.0019111 | 0.273 | TRUE | 0.176588404 |
| 2-hydroxystearate | Graves’ disease | 11 | 1.01(1.00-1.01) | 0.047 | 7.492 | 0.678 | 0.0021971 | 0.272 | TRUE | 0.27966876 |
| 1-oleoylglycerol (1-monoolein) | Graves’ disease | 11 | 1.02(1.00-1.03) | 0.008 | 7.539 | 0.674 | 0.0009299 | 0.832 | TRUE | 0.946667749 |
| 2-hydroxyisobutyrate | Graves’ disease | 6 | 1.00(0.99-1.01) | 0.041 | 2.819 | 0.728 | 0.008937 | 0.268 | TRUE | 0.916619542 |
| 3-(4-hydroxyphenyl)lactate | Graves’ disease | 8 | 1.00(0.99-1.00) | 0.043 | 5.290 | 0.382 | -0.0063934 | 0.437 | TRUE | 0.379018338 |
| Scyllo-inositol | Graves’ disease | 9 | 1.01(1.00-1.02) | 0.046 | 4.350 | 0.825 | -0.00558 | 0.149 | TRUE | 0.452788967 |
| 1-arachidonoylglycerophosphocholine* | Graves’ disease | 11 | 1.01(1.00-1.02) | 0.007 | 6.976 | 0.728 | -0.0007676 | 0.760 | TRUE | 0.598643183 |
| 1-palmitoleoylglycerophosphocholine* | Graves’ disease | 11 | 1.01(1.00-1.02) | 0.003 | 5.263 | 0.873 | -0.0014652 | 0.578 | TRUE | 0.523981309 |
| 1-docosahexaenoylglycerophosphocholine* | Graves’ disease | 11 | 1.01(1.00-1.02) | 0.014 | 4.268 | 0.934 | -0.0015551 | 0.592 | TRUE | 0.238630271 |
| N2,N2-dimethylguanosine | Graves’ disease | 6 | 0.99(0.99-1.00) | 0.049 | 2.120 | 0.832 | 0.00183 | 0.371 | TRUE | 0.536838388 |
| Glutaroyl carnitine | Graves’ disease | 11 | 1.01(1.00-1.01) | 0.044 | 10.978 | 0.359 | -0.0020548 | 0.335 | TRUE | 0.290557508 |
| 1-myristoylglycerophosphocholine | Graves’ disease | 11 | 1.01(1.00-1.02) | 0.029 | 3.766 | 0.957 | -0.0009854 | 0.737 | TRUE | 0.144661835 |