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. 2023 Oct 9;14:1165683. doi: 10.3389/fimmu.2023.1165683

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Copyright © 2023 Geckin, Kilic, Debisarun, Föhse, Rodríguez-Luna, Fernández-González, Sánchez and Domínguez-Andrés

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AM3 is similarly effective in cells from both young and elderly individuals. Cytokine production measured in supernatants from PBMCs after 24 hours and after 48 hours following primary stimulation (RPMI, AM3 and LPS) and combination treatments, in cultures derived from young (n=9, pink data points) and elderly (n=9, purple data points) healthy donors. Mann-Whitney test used to compare elderly and young individuals. *p<0.05, **p<0.01. The gray line depicts the median whereas colored lines represent the borders of interquartile range.