TABLE 4.
In vivo activity of ABT-255 against ethambutol-resistanta M. tuberculosis ATCC 35837 in CF-1 mice
| Drug and doseb (mg/kg day−1) or group | Mean log10 no. of CFU/lung ± SE | Mean log10 reductionc |
|---|---|---|
| ABT-255 | ||
| 25 | 4.13 ± 0.15 | 3.10 |
| 12.5 | 5.62 ± 0.21 | 1.61 |
| 6.25 | 6.52 ± 0.21 | 0.71 |
| Isoniazid, 25 | 2.08 ± 0.48 | 5.15 |
| Ethambutol, 150 | 7.28 ± 0.17 | 0 |
| Infected controls | 7.23 ± 0.14 |
a
Inoculum of log10 7.60 mycobacteria.
b
Mice were dosed orally daily, from 7 to 34 days postinfection.
c
Difference in mean log number of CFU from that of the day 35 late control group.